Loesyn™ is a proprietary composition containing a unique combination of Aloe chromone in Aloe vera leaf gel powder clinically proven to maintain healthy glucose levels and normal insulin sensitivity already in normal ranges.
What Makes Loesyn™ Unique?
- Loesyn™ is a patented Aloe composition with pre-clinical and clinical evidence for maintain novel insulin sensitivity within already normal ranges.
- Loesyn™ was shown to be maintaining already healthy fasting plasma glucose and normal fasting insulin with improvement in HOMA (insulin sensitivity index) in human clinical study.
- Loesyn™ was found to be effective in maintaining healthy and novel long term and short-term glycemic control (HbA1C and fructosamine) in human clinical study.
- Loesyn™ was shown to result in statistically significant reduction in oxidative stress (F2-isoprostanes) in human clinical study.
Loesyn™ Key Benefits*
- Supports already normal insulin sensitivity
- Maintains normal healthy blood glucose levels
- Reduces oxidative stress
- Maintains already healthy blood triglycerides (based on pre-clinical studies)
- Safe, well-tolerated and natural with high compliance to oral supplement
- Easily formulated with other ingredients
Plant Origin
Derived from leaf of Aloe barbadensis and Aloe ferox.
Applications
An alternative natural aid for maintaining already healthy glycemic control and insulin sensitivity in normal healthy individuals.
Formulation
Can be used as an active agent in tablets, capsules, liquids, powders, bars, gummies, gels, RTD and other delivery systems.
Physical Properties
Off-white to tan colored powder that is water soluble.
Regulatory Status
Self-Affirmed Medical Food GRAS Ingredient.
*Indications and claims related to the health benefits or property of an ingredient or product are intended for industry only and are governed in accordance with country-specific laws and regulations and may not be appropriate for final consumer products. In the United States, it is your responsibility to ensure that product claims and indications are in compliance with all applicable laws and regulations, including the Federal FD&C Act and the FTC Act. In all other countries, please consult with a local regulatory or legal professional who may provide you with competent advice and guidance.
Discovery
Loesyn’s™ unique formulation was developed through Unigen’s proprietary Phytologix® technology platform, based on a collection of more than 12,000 plants and marine samples with documented human consumption. Unigen scientists used this library of comprehensive botanical profiles to identify plants that can provide beneficial biological activity to sustain a healthy living.
Loesyn™ is a patented plant-based supplement derived from a unique combination of Aloe chromone from Aloe ferox and Aloe vera leaf gel powder from Aloe barbadensis.
Over 2,059 medicinal plants from Unigen’s PhytoLogix® library were screened to identify natural substances increase adiponectin production by adipocytes. Adiponectin is a protein in blood to help maintain normal healthy insulin sensitivity. The active components from the screen were identified by HPLC-Mass Spectrometry and NMR and shown to be highly specific components in extracts from Aloe.
The combination of these two extracts produced healthy glucose levels and normal insulin sensitivity maintenance already within normal ranges.*
Mechanism of Action
The healthy glucose levels and normal insulin sensitivity maintenance activity of Loesyn™ is derived from:
- Increasing adiponectin production by adipocytes
- Increasing multiple key genes in the insulin receptor signaling cascade such as Insulin receptor (INSR), Insulin receptor substrate 1 (IRS1) and Glucose transporter 4 (GLUT4)
- Modifying multiple metabolic pathways in liver for lipid metabolism including decreased fatty acid biosynthesis, Increased fatty acid binding proteins, and decreased lipid uptake.
Scientific Research
Pre-Clinical Data
Loesyn™ supplement relative to vehicle given mice demonstrated the following results:
- Reduced fasting plasma glucose levels comparable to that achieved with GW1929 treatment (Figure 4)
- Significantly improved glucose tolerance, as measured by intraperitoneal glucose tolerance tests, comparable to that achieved with GW1929 (Figure 5)
- Significantly improved insulin sensitization as measured by intraperitoneal insulin tolerance tests (Figure 6)
- Reduced fasting blood triglyceride concentrations comparably to GW1929 (Figure 7)
- Significantly reduced hepatic triglyceride and cholesterol content to levels comparable to that of lean mice fed with normal chow (Figure 8)
Clinical Data
In a randomized, double-blind, placebo controlled, IRB approved clinical trial:
- Loesyn™ has been shown to be safe and well-tolerated.
- Loesyn™ has been shown significant maintenance of normal healthy levels of fasting plasma glucose and insulin with improvement in HOMA (insulin sensitivity index).*
- Loesyn™ has been shown significant support in healthy long term and short-term glycemic maintenance (reduced HbA1C and fructosamine).*
- Loesyn™ has shown reduction in oxidative stress (F2-isoprostanes) in certain populations.*
Product Safety
Safety is a top priority at Unigen. All the ingredients we develop undergo rigorous safety testing using state-of-the-art in vitro, pre-clinical, and/or human safety studies (for some ingredients).* Loesyn™ was found safe through these stringent safety studies.*
References
- 7-Hydroxy Chromones as Potent Antioxidants. Q. Jia, USA patent 6,884,783
- Chromones as Therapeutic Agents. JF Zhao, J Tseng-Crank, M Yimam, Q. Jia. US 2008/0166438.
- Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q. E¬ects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord. 2013 Feb;11(1):35-40.
- Dick WR. et al. Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis The Journal of Alternative and Complementary Medicine. 2016, 22(6), 450-457
- Julie Tseng-Crank, Seon-Gil Do, Brandon Corneliusen, Carmen Hertel, Jennifer Homan, Mesfin Yimam, Jifu Zhao, Qi Jia. UP780, a Chromone-Enriched Aloe Composition, Enhances Adipose Insulin Receptor Signaling and Decreases Liver Lipid Biosynthesis. Open Journal of Genetics, 2013, 3, 9-86.
- Mesfin Yimam, Jifu Zhao, Brandon Corneliusen, Mandee Pantier, Lidia Alfaro Brownell, Qi Jia. UP780, a Chromone-enriched aloe composition improves insulin sensitivity. Metabolic Syndrome and Related Disorders. Vol. 11, No. 4. 267-275, 2013.
Copyright © 2024 Unigen® All Rights Reserved. This information is provided for scientific and educational purposes related to this ingredient. When marketing this ingredient in a finished product to end consumers, it is your responsibility to ensure that product claims and indications are in compliance with all applicable laws and regulations including the Federal FD&C Act and the FTC Act.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. These statements are presented for informational purposes only and are not intended to be presented to final consumers.