Maizinol™ is a Zea mays (corn leaf)-derived, patented, clinically proven natural sleep aid ingredient that contains proprietary standardized natural compounds known to bind to melatonin receptors and produce melatonin-like effects for better sleep quality.*

What Makes Maizinol™ Unique?

• Maizinol™ is a hormone free natural supplement clinically proven to increase the restorative stage of sleep.*
• Maizino™ was found to be effective in improving sleep quality in human clinical studies by enhancing the deep sleep stage of sleep.*
• Maizino™ was shown to improve sleep quality as it was measured by the Pittsburgh Sleep Quality Index (PSQI) in human clinical studies.*
• Maizinol™ is known to contain biologically active compounds proven to bind to melatonin receptors with a 4-fold higher affinity for MT2 Receptor.*

Maizinol™ Key Benefits

• Once-a-day dosing increases consumer compliance.
• High compatibility in formulating with other ingredients.
• Natural plant source with a long history of safe human use.*
• Extensive in vivo safety testing with no adverse effects.*
• Patent protected.

Plant Origin

Zea mays (corn or maize) leaves.

Applications

• Sleep Aid

Formulation

Can be used as an active agent in tablets, capsules, liquids, gels, gummies, powders, bars, RTD and other delivery systems.

Physical Properties

Brown powder. *Indications and claims related to the health benefits or property of an ingredient or product are intended for industry only and are governed in accordance with country-specific laws and regulations and may not be appropriate for final consumer products. In the United States, it is your responsibility to ensure that product claims and indications are in compliance with all applicable laws and regulations, including the Federal FD&C Act and the FTC Act. In all other countries, please consult with a local regulatory or legal professional who may provide you with competent advice and guidance.

Discovery

Maizinol™’s unique formulation is derived from the leaf of immature Zea mays plants. Unigen researched the best species of corn and found optimized growth and harvesting conditions to produce a high quality of biomass for extraction with a consistent and standardized content of actives that provides the sleep support benefit of Maizinol™.

Mechanism of Action

The sleep quality effects of Maizinol™ are derived from three defined mechanisms of action:

1. binding to melatonin receptors
2. reducing cortisol levels
3. regulating melatonin synthesis pathways via 6-MBOA

Scientific Research

Clinical Data

Summary Highlights

• Maizinol™ supplementation improved the state of deep sleep and hence quality of sleep in a dose-correlated manner.*
• Maizinol™ showed a statistically significant increase in total sleep time compared to baseline.*
• Maizinol™ supplementation improved sleep quality and efficiency as measured by Pittsburgh Sleep Quality Index.*

Conclusion

There was a clear and consistent benefit of Maizinol™ (UP165) on Sleep Quality improvement, particularly showing that subjects spent more time in deep sleep stages with Maizinol™ supplementation. Improvements in sleep quality were reflected in both subjective and objective measures. Data from this double-blind placebo controlled clinical trial have shown that supplementation of subjects with Maizinol™ to produce a statistically significant improvement in sleep quality compared to the placebo group. By the end of the 4-week supplementation period, subjects in the Maizinol™ group benefited significantly more than those in the Placebo group.*

Product Safety

Safety is a top priority at Unigen. All the ingredients we develop undergo rigorous safety testing using state-of-the-art in vitro, pre-clinical, and human safety studies (for some ingredients).* Mainzinol™ was found safe through these stringent safety studies.

References

1. Talbott SM, Talbott JA, Brownell L, Yimam M. UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State. J Med Food. 2022 Sep 30. doi: 10.1089/jmf.2021.0197. Epub ahead of print. PMID: 36179066.
2. Cecon, E., Oishi, A., & Jockers, R. Melatonin receptors: molecular pharmacology and signaling in the context of system bias. British Journal of Pharmacology. 2018;175:3263-3280.
3. Daya, S., Pangerl, B., Pangerl, A., Troiani, M.E., & Reiter, R.J. Effect of 6-methoxy-2-benzoxazolinone on the activities of rat pineal N-acetyltransferase and hydroxyindole-O-methyltransferase and on Melatonin production. J Pineal Res. 1990;8(1):57-66.
4. Kalman, D., Feldman, S., Vazquez, R.R., & Krieger, D. A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-L-Methionine on Depression, Anxiety and Psychological Well-Being. Foods. 2015, 4, 130-139; doi:10.3390/foods4020130.
5. Gobbi, G., & Comai, S.. Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep. Front Endocrinol (Lausanne). 2019 Mar 1;10:87.
6. Yimam, M., Jiao, P., Hong, M., Brownell, L., & Jia, Q. Effect of UP165, a zea mays leaf extract standardized for 6-methoxybenzoxazolinone, as sleep adjunct. Phcog Res. 2018;10:156-60.
7. Talbott, S.M., & Talbott, J.A. Effect of monocot grass extract (MGE) on mood state and sleep patterns in moderately stress subjects. J Int Soc Sports Nutr 2013;10 Suppl 1:P26. Back to cited text no. 33.

Copyright © 2022 Unigen® All Rights Reserved. This information is provided for scientific and educational purposes related to this ingredient. When marketing this ingredient in a finished product to end consumers, it is your responsibility to ensure that product claims and indications are in compliance with all applicable laws and regulations including the Federal FD&C Act and the FTC Act.