Overview
Science & Discovery
Overview
AmLexin® is a patented, natural joint-care ingredient clinically proven to help protect joints from natural wear and tear.
What Makes AmLexin® Unique?
- AmLexin® has been shown to be effective in an ex vivo GAG assay, at reducing Glycosaminoglycan (GAG) released by articular cartilage.
- Clinical trial results demonstrated statistically significant reduction of uCTX-II, a type II collagen biomarker of joint cartilage break down. This indicates a protective quality that may help reduce the degradation of joint cartilage.*
AmLexin® Key Benefits*
- AmLexin® is a potent anti-oxidant that specifically neutralizes super oxide anion – a free radical generated by normal wear and tear.
- AmLexin® effectively inhibits cartilage catabolic pathways by modulating cox-1, cox-2, and 5-lox enzyme activity.
- AmLexin® has been shown to have cartilage protective properties in ex vivo studies.
Plant Origin
Derived from the root bark of Morus alba and heartwood of Acacia catechu.
Applications
- Alleviate joint discomfort and stiffness
- Provide protection for joint cartilage
- Enhance flexibility and physical function
Formulation
Can be used in tablets, capsules, powders, bars and other delivery systems.
Physical Properties
Brown color powder, insoluble in water.
*Indications and claims related to the health benefits or property of an ingredient or product are intended for industry only and are governed in accordance with country-specific laws and regulations and may not be appropriate for final consumer products. In the United States, it is your responsibility to ensure that product claims and indications are in compliance with all applicable laws and regulations, including the Federal FD&C Act and the FTC Act. In all other countries, please consult with a local regulatory or legal professional who may provide you with competent advice and guidance.
Science & Discovery
Discovery and Formulation
Unigen, Inc. possesses over 12,000 plant and marine samples known to be consumed by humans, each documented extensively. Following a thorough review of literature and historical data, we identified 132 plant extracts traditionally used for arthritis and discomfort relief. These extracts were chosen for screening fir discomfort mitigation using in vivo anti-pain models. A total of 34 plant extracts exhibiting in vivo efficacy were identified and proceeded to biological assay-guided active isolation and identification. Over 10 standardized extracts were created following thorough chemical and functional profiling. Combinations of multiple active extracts were subsequently developed and assessed independently in both in vitro and in vivo assays to uncover innovative and potent natural ingredients with significant efficacy in joint protection and enhancement of joint function. This research initiative resulted in the discovery of the standardized formulation AmLexin® from Acacia catechu and Morus alba.Mechanism of Action
The healthy cartilage maintenance properties of AmLexin® is derived from:- Reduction of extra cellular matrix degrading enzymes (e.g. MMP-13)
- Inhibition of key pro-inflammatory cytokines (such as TNF-α, IL-1β and IL-6) known to downregulate the synthesis of major extracellular matrix, decrease anabolic activity of chondrocytes, activate extra cellular matrix degrading enzymes, and inhibit antioxidant activity of the host we inducing free radicals.
- Inhibition of COX-LOX inflammatory enzymes
- Neutralization of highly reactive and oxidative free radical Super Oxide Anion.
Scientific Research
Pre-Clinical Data
AmLexin® supplement has been tested in several scientifically sound, pre-clinical in-vivo and in-vitro tests for its usage in joint support and demonstrated the following results:- Reduced Glycosaminoglycan (GAG) release by articular cartilage (Figure 1)
- Effectively inhibited cartilage catabolic pathways by modulating COX-1, COX-2, and 5-LO enzyme activity (Figure 2)
- Possesses a significantly higher capacity to neutralize highly reactive and oxidative Super Oxide Anion (Table 1)
- Showed significant comfort promoting activity in carrageenan induced rat paw edema model (Figure 4).
- Showed significant improvements in maintenance of the articular structural integrity of rats while preserving comfort in monoiodoacetate induced arthritis model (Figure 5 and 6).
- Produced statistically significant modulation the level of proinflammatory cytokines (TNF-α, IL1-β, IL-6) and cartilage breakdown marker uCTX-II in collagen induced arthritis model (Figure 7)
Clinical Data
In a randomized, double-blind, placebo controlled, IRB approved clinical trials- AmLexin® has been shown to be safe and well-tolerated. *
- AmLexin® has been proven to provide joint cartilage protection. *
- AmLexin® has been shown to significantly reduce cartilage breakdown marker uCTX-II compared to placebo. *
- AmLexin® has been proven to be effective for normal delayed onset muscle soreness after regular exercise. *
- AmLexin® has been validated to provide quick exercise recovery in healthy participants. *
- AmLexin® was found to reduce WOMAC discomfort scores as of day 1 post exercise compared to placebo. *
- AmLexin® has been found to significantly reduce oxidative stress while replenishing anti-oxidative reserve in healthy runners. *
Product Safety
Safety is a top priority at Unigen. All the ingredients we develop undergo rigorous safety testing using state-of-the-art in vitro, pre-clinical, and/or human safety studies (for some ingredients).* AmLexin® was found safe through these stringent safety studies.*References
- Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis. 2001 Jun;60(19-26.
- Kalman DS, Hewlings SJ. The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. J Nutr Metab. 2017;2017:4893104.
- Laupheimer MW, Perry M, Benton S, Malliaras P, Maffulli N. Resveratrol exerts no effect on inflammatory response and delayed onset muscle soreness after a marathon in male athletes.: A randomised, double-blind, placebo-controlled pilot feasibility study. Transl Med UniSa. 2014 Apr :38-42.
- Mendes AF, Caramona MM, Carvalho AP, Lopes MC. Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kappa B activation and iNOS expression in bovine articular chondrocytes. J Cell Biochem. 2003 Mar 1;88(4):783-93.
- Pereira Panza VS, Diefenthaeler F, da Silva EL. Benefits of dietary phytochemical supplementation on eccentric exercise-induced muscle damage: Is including antioxidants enough? Nutrition. 2015 Sep;31(9):1072-82.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. These statements are presented for informational purposes only and are not intended to be presented to final consumers.
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